Figure 19.

Representation of the three-dimensional structures of the histamine receptors that could be considered for ALS treatment. (A) The H₁ receptor (sourced from the Protein Data Bank, PDB code: 7DFL [132], method: cryo-EM, resolution: 3.30 Å) and (B) the H₂ receptor (with no experimentally resolved structure available, the model sourced from the AlphaFold [133] database is presented).The images were created and rendered with MOE. The H₃ and H₄ receptors both lack experimentally resolved structures, but their AlphaFold models are available.