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S. aureus secretomes increased expression of SCC biomarkers in human keratinocytes. Heatmaps show the gene (top) and protein (bottom) expression changes of biomarkers linked with SCC progression [30,31,32,33,34,35] in keratinocytes challenged with S. aureus secretome compared to control. * p < 0.05. Note, most of the biomarkers are highly secreted proteins, hence, they were not detected by shotgun proteomics of the cellular fraction.
