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. 2022 Apr 25;14(9):2143. doi: 10.3390/cancers14092143

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pathway enrichment of transcripts and proteins informs cellular changes in response to challenge with S. aureus secretomes. Enrichment of biological pathways in keratinocytes based on the changes in genes (left panel) and proteins (right panel) was evaluated using the KEGG database. All differentially expressed pathways of significance (i.e., adj. p < 0.05) are shown and the direction of differential expression is indicated by colour of the box (blue = downregulated; red = upregulated). No significant pathways were found for SSA55 and SSA103 based on the proteomics data. Detailed pathway analysis results based on the Reactome database are available in Table S3.