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. 2022 May 9;14(9):2337. doi: 10.3390/cancers14092337

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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OSF-2 expression correlates with HPV status and markers of metastatic disease. Bioinformatic analysis of the TCGA HNC patient cohort (n = 612). High OSF-2 expression significantly correlates with (A) HPV status, (B) perineural infiltration, (C) extracapsular spread (ECE), and (D) pathological lymph node status (pLNx) for p16 negative or unknown. N2a/b/c and N3a/b are pooled, respectively; AJCC 8th Edition. p-values and sample size (n) as indicated. * p < 0.05, ** p < 0.01, **** p < 0.0001, and ns indicates not significant.