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. 2022 May 13;17(1):897–906. doi: 10.1515/med-2022-0480

Figure 3.

Figure 3

Lidocaine regulated M1/M2 microglia polarization in a rat model of CCI-induced NP. The rats in different groups were sacrificed at 14 days, and L4–L6 segments of the rat spinal cord were separated and microglia were isolated. (a) Flow cytometry was used to detect the proportion of M1 and M2 microglia, as evidenced by the fraction of CD68+ cells and CD206+ cells. RT-PCR was used to detect the expression of M1 marker iNOS (b) and M2 marker Arg-1 (c). Data are expressed as mean ± SD and were analyzed using one-way ANOVA with Tukey’s post hoc test.*p < 0.05 versus Sham group; #p < 0.05 versus NP group.