Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 3;18(5):e1010488. doi: 10.1371/journal.ppat.1010488

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

PMC Copyright notice

Fig 1 — (A) Linear representations of the R66M NFL and the Z1800M UFO Env trimers are shown. Cysteine residues are indicated along the top; the (G₄S)₂ linker is indicated by a black dashed line; the optimized gp41 region in the UFO is indicated by a green dashed line; key amino acid substitutions with HXB2 numbering are indicated along the Env open reading frame and are color-coded to indicate their putative contribution to stabilization. The CD5 leader sequence is also shown. (B) Size exclusion chromatography profiles are shown for the BG505 NFL trimer as a process control, the R66M NFL trimer, and the Z1800M UFO trimer. The fractions corresponding to the trimeric proteins are shaded.