Fig 4. Breaking coordination: attention in metastatic cancer cell line MDA-MB-231.

(A) Normalized attention weight contour plot, (B) neighbor location histogram, (C) closest neighbor scatter plot, as colored by normalized attention weights, and (D) histogram of highest weighted neighbors, with all plots analogous to those in Figs 2 and 3. Results shown for MDA-MD-231 cells with cell trajectory points taken every 5 minutes, and networks encompassing 10 neighbors with 20 minute prediction times. This cancer line functions as a control, as the cancer cells are highly uncoordinated, resulting in nearly equal attention weight applied to local neighbors in all directions. (E) Network accuracy plots as prediction time interval is varied, aggregated over networks accounting for 5–50 neighbors in increments of 5. Solid lines reflect accuracy scores for all turning angles in the focal agent trajectory; dashed lines reflect only large turns (±20–160°). Accuracy decreases with increasing prediction interval and varies little as a function of neighbors observed by the network. Cell trajectory timesteps were fixed at 5 minutes.