Table 1.

Structural Effect of Josiphos on Transformation^a

entry	R; R'	yield (SM %)b	ee (%)c
1	Me; H	59% (23)	45
2	Me; OMe	31% (14)	44
3	tBu; OMe	41% (<1)	70
4	Mes; H	58% (38)	75
5	TTB; H	3% (79)	nd
6	TMS; H	73% (<1)	75
7	TES; H	66% (<1)	83
8	CF3; H	43% (<2)	71
9	iPr(F7); H	44% (43)	86

^aStandard conditions: 1a (0.10 mmol, 1.0 equiv), 2 (0.135 mmol, 1.35 equiv), CuCl (5 mol %), L (6 mol %), THF (1.0 mL), 65 °C, 24 h.

^bYield was determined by ¹⁹F NMR of crude reaction, using PhF as an internal standard.

^cDetermined by HPLC with a chiral stationary phase.