Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 29;12:888922. doi: 10.3389/fonc.2022.888922

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Xu, Zhao, Song, Xiao, Cui, Xin, Xu, Zhang, Yi, Hong, Tong, Tian, Tan, Kang and Fang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Triacsin C and Etomoxir reduce PRADX-mediated tumorigenesis in vitro and in vivo. (A) CCK8 assays show the effect of PRADX overexpression and the Triacsin C and Etomoxir on cell viability. (B) Colony formation assays show the effect of PRADX overexpression and the Triacsin C and Etomoxir on the tumor cell growth of the indicated five groups, representative images are shown. (C) Nude mice were orthotopically injected with PRADX overexpression or scramble TBD0220 cells. Representative luminescence images at 7,14,21 and 28d after injection are shown. (D, E) Kaplan-Meier survival curve and quantification of bioluminescence signal intensities at 7,14, and 21d post-injection are shown. (F) IHC of tumor tissues from nude mice xenograft models showing BLCAP, ACSL1, STAT3, p-STAT3, and Ki-67 expressions in the five groups. (G) Scheme showing PRADX-EZH2 interaction-mediated recruitment of H3K27me3 and regulation of STAT3 activity, promoting mesenchymal GBM tumorigenesis. The values in A are represented as mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P <0.0001.