Table 1. Decreased survival of CYP19A1(Tg)^Cre; Cdh5^fl/fl mutants in late gestation.

Cdh5^fl/fl male mice were crossed with CYP19A1(Tg)^Cre; Cdh5^fl/+ females to generate litters with mixed genotypes. The expected percentage is listed under the genotype label. The observed number of each genotype is shown with the corresponding percentage given in parentheses. P-values were calculated using Fisher’s exact test at stages E10.5-12.5 (pooled), E14.5-16.5 (pooled), and P21. E designates embryonic day and P designates postnatal day.

	CYP19A1(Tg)Cre; Cdh5fl/fl (25%)	CYP19A1(Tg)Cre; Cdh5fl/+ (25%)	Cdh5fl/fl (25%)	Cdh5fl/+ (25%)	Total (100%)	Fisher Exact Test
E10.5-E12.5	13* (26%)	13 (26%)	12 (24%)	12 (24%)	50 (100%)	P=1.0000
E14.5-E16.5	1 (2.9%)	13 (38.2%)	12 (35.3%)	8 (23.5%)	34 (100%)	P=0.0033
P21	1 (2.2%)	11 (24.4%)	15 (33.3%)	18 (40.0%)	45 (100%)	P=0.0333

^*One embryo at E12.5 was dead.