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. 2022 May 16;132(10):e145889. doi: 10.1172/JCI145889

Figure 12. Hepatic KISS1/KISS1R expression and plasma kisspeptin levels are increased in male patients with NAFLD.

Figure 12

(A) Representative Western blots and densitometric analysis of blots. (B) Expression of human KISS1 and KISS1R by RT-qPCR. Data are shown as the mean ± SEM. Student’s unpaired t test; *P < 0.05 compared with controls. (C) Representative images showing immunostaining of endogenous KISS1R in liver. Scale bars: 80 μM. (D) Plasma kisspeptin (KP) levels (pmol/L; mean ± SEM) in humans. Statistical analysis done using a nonparametric Kruskal-Wallis test. Data are shown as the mean ± SEM. T2D, type 2 diabetes; NAFL, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis. aP < 0.001 for NAFL compared with healthy; bP < 0.001 for NAFL compared with T2D; cP < 0.001 for NASH compared with healthy; AP < 0.001 for NASH compared with T2D.