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. 2022 May 16;132(10):e145889. doi: 10.1172/JCI145889

Figure 8. Kisspeptin agonist treatment alleviates NASH in diet-induced animal model of nonalcoholic liver disease mice.

Figure 8

Diet-induced animal model of nonalcoholic liver disease (DIAMOND) mice maintained on a Western diet with sugar water (WDSW) for 33 weeks were treated with vehicle (PBS) or kisspeptin agonist (KPA) for 6 weeks, while they were kept on a WDSW diet. KPA, kisspeptin agonist. (A) Liver weight at endpoint. (B) Serum ALT levels. (C) Representative histology of Picrosirius red–stained liver section. Quantification of staining is shown. Scale bars: 500 μm. (D) Liver hydroxyproline levels. (E) Expression of indicated hepatic genes by RT-qPCR. (F) Plasma IL-1α levels. (G) Representative Western blots showing expression of indicated proteins. (H) Expression of indicated hepatic genes by RT-qPCR. Densitometric analyses of blots shown in Supplemental Figure 10, A–G. Data are shown as the mean ± SEM. Student’s unpaired t test; *P < 0.05 versus respective controls.