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. 2022 May 16;132(10):e155333. doi: 10.1172/JCI155333

Figure 6. Cardiac-specific deletion of ATPIF1 partially restored respiratory function induced by pathological cardiac hypertrophy.

Figure 6

(A) Immunoblot of ATPIF1 expression from liver or ventricular lysates (n = 4–5). (B) Analysis of isolated mouse heart mitochondrial OCR by Seahorse analyzer (n = 5). (C and D) Representative OCR tracing and tabulated data of isolated mouse heart mitochondrial OCR at 28 days after TAC (C), MI (D), or sham surgery. (E) Average OCR of TAC and MI groups during ADP or FCCP stimulation, normalized to the respective sham group (n = 6). Data are means ± SEM of the values. P values were determined using unpaired 2-tailed Student’s t test (E) or 1-way ANOVA followed by Dunnett’s multiple-comparison test (A); **P < 0.01, ***P < 0.001, ****P < 0.0001.