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. 2022 May 16;132(10):e156125. doi: 10.1172/JCI156125

Figure 2. Exercise does not exacerbate myopathy and augments myofiber size in DM1 patients.

Figure 2

(A) Representative images of H&E staining of the vastus lateralis muscle from CON (left) and DM1 patients before exercise with mild myopathy (DM1-PRE, middle left), DM1-PRE with severe myopathy (middle right), and patients following exercise (DM1-POST, right). Arrows indicate CNF. (B) Graphical summary of the frequency of CNF. (C) Average scores of pathology examination for CON, DM1-PRE, and DM1-POST. (D) Representative images of IF staining for wheat germ agglutinin (WGA) (cyan) and MHC type I (blue), type IIA (green), and type IIX (red). Original magnification, ×20. (E) Pie charts of fiber-type distribution in each group. (F) Average fiber-type–specific and total CSA. (G and H) Size distribution of fiber CSA for type I and type IIA fibers, respectively. Data are expressed as box and whisker plots with plus signs representing the mean (B and F–H) or bar graphs as mean ± SEM (C). n = 11. *P < 0.05 versus CON, 1-way ANOVA followed by Bonferroni’s correction; #P < 0.05 versus DM1-PRE, 2-tailed paired t test corrected for multiple comparisons.