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. 2022 May 5;49(6):86. doi: 10.3892/ijmm.2022.5142

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Copyright: © Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Preventative administration of IL-27 before the OVA challenge upregulates Tr1 cells in mouse lung tissue. (A) FACS analysis of Tr1 cells in the lung tissue of PBS group. (B) FACS analysis of Tr1 cells in the lung tissue of OVA group. (C) FACS analysis of Tr1 cells in the lung tissue of OVA + IL-27 group. (D) The proportion of Tr1 cells in the mouse lung tissue analyzed using flow cytometry. The proportion of Tr1 cells in the OVA + IL-27 group was significantly higher than that in the OVA group (P<0.001). The data are expressed as the mean ± SEM of three independent experiments, with 8 animals per group. ^***P<0.001. FACS, fluorescence-activated cell sorting; IL-27, interleukin-27; OVA, ovalbumin; Tr1, type 1 regulatory T-cells.