Table 3.
Author | Design | Population | Thromboprophylaxis during Hospitalization | Post discharge Thromboprophylaxis | Indication for VTE Detection | N | D-Dimer, ng/mL | Follow-up |
---|---|---|---|---|---|---|---|---|
Engelen[57] | Prospective | COVID-19 patients post discharge | prophylactic or intermediate dose of LMWH (no description of dosages) | 8% received prophylactic LMWH post discharge | Screening US for all patients CTPA or VQ screening for ICU patients or those with D-dimer ≥ 2 μg/mL |
102 | 590 | 6 weeks post-hospital discharge |
Patell[59] | Retrospective | Discharged patients with confirmed COVID-19 | NR | 13 patients received prophylactic dose anticoagulation (10 LMWH, 2 DOACs, 1 UFH); they were excluded from the analysis | VTE diagnosis based on clinical suspicion | 163 | 30 days | |
Roberts[58] | Retrospective | COVID-19 patients post-discharge | Thromboprophylaxis during admission to all Weight based dosing (<50 kg: enoxaparin 20 mg OD or 5000 units BID, 50–100 kg: 40 mg OD or 5000 units BID, 101–150 kg: 40 mg BID or 80 mg OD or UFH 5000 units TID, >150 kg: 60 mg BID or 120 mg OD or 5000 units TID) |
None | Testing for VTE was only done in symptomatic patients | 1877 | NR | 6 weeks post-hospital discharge |
Rashidi[60] | Prospective | Discharged patients with suspected or confirmed COVID-19 | 1490 (97%) received VTE prophylaxis (enoxaparin 40–60 mg/daily, UFH 5000 IU/QID) | None | VTE diagnosis based on clinical suspicion | 1529 | NR | 45–55 days |
Giannis[61] | Prospective | Discharged patients with confirmed COVID-19 | 82% of patients received VTE prophylaxis | 12.7% received extended VTE prophylaxis with DOAC or LMWH (enoxaparin 40 mg SQ daily) for 30 days in patients with an IMPROVE VTE score of ≥ 4 or D-dimer ≥ 2X ULN. | VTE diagnosis based on clinical suspicion | 4906 | 340 ± 710 | Up to 90 days post-discharge |
Eswaran[62] | Retrospective | Discharged patients with confirmed COVID-19 | NR | 190 (42.5%) patients were discharged on VTE prophylaxis. | VTE diagnosis based on clinical suspicion | 447 | 30 days post-discharge |