Table 11.
Micronucleated polychromatic erythrocytes (MNPCEs) in LN18178-treated mice bone marrow.
| Treatments | Dose (mg/kg.BW) | Number of mice | PCE/TE | % Reduction | % MNPCE |
|---|---|---|---|---|---|
| Vehicle controla | 0 | 10 | 46.3 | — | 0.10 ± 0.07 |
| 500 | 10 | 46.2 | 0.2 | 0.11 ± 0.05 | |
| LN18178 | 1000 | 10 | 46.8 | −1.1 | 0.07 ± 0.06 |
| 2000 | 10 | 46.3 | 0 | 0.07 ± 0.06 | |
| Cyclophosphamideb | 40 | 10 | 41.2 | 11.2 | 1.48 ± 0.19∗ |
∗ indicates significant changes (p < 0.05) compared with the vehicle control. aDistilled water, bpositive control; BW, body weight; MNPCE, micronucleated polychromatic erythrocyte; PCE, polychromatic erythrocyte; TE, total erythrocytes. Each group contains 10 animals (5 male and 5 female).