Table 2.
Effect of 90-day oral administration of LN18178 on food consumption by the male and female Wistar rats.
| Day | Sex | LN18178 dose (mg/kg BW) | |||||
|---|---|---|---|---|---|---|---|
| Main groups (n = 10) | Reversal groups (n = 5) | ||||||
| 0 | 625 | 1250 | 2500 | 0 | 2500 | ||
| 1–28 | M | 569.72 ± 11.22 | 561.58 ± 32.82 | 567.08 ± 20.37 | 557.12 ± 16.76 | 583.35 ± 29.81 | 600.59 ± 48.34 |
| F | 409.25 ± 20.98 | 397.91 ± 34.70 | 424.70 ± 22.53 | 408.33 ± 36.03 | 406.94 ± 1.97 | 401.87 ± 3.30 | |
| 29–56 | M | 573.96 ± 7.68 | 561.10 ± 17.92 | 572.30 ± 14.53 | 579.39 ± 24.80 | 585.00 ± 40.78 | 600.59 ± 3.27 |
| F | 397.95 ± 15.95 | 384.30 ± 25.07 | 406.68 ± 14.75 | 405.36 ± 35.61 | 402.66 ± 8.04 | 393.76 ± 5.39 | |
| 57–90 | M | 664.16 ± 11.12 | 658.03 ± 17.16 | 658.05 ± 14.96 | 655.55 ± 39.59 | 700.68 ± 17.47 | 702.07 ± 21.83 |
| F | 475.25 ± 20.07 | 473.43 ± 31.39 | 477.55 ± 10.56 | 478.88 ± 27.76 | 497.61 ± 9.28 | 489.33 ± 10.70 | |
| 91–118 | M | — | — | — | — | 538.18 ± 10.91 | 528.25 ± 11.73 |
| F | — | — | — | — | 370.78 ± 16.49 | 373.26 ± 33.81 | |
Data are presented as mean ± SD of food consumption in g. Each main group contains 20 rats (10 males and 10 females), and reversal group contains 10 rats (5 males and 5 females). BW, body weight; M, male; F, female.