Table 3.
Effect of oral administration of LN18178 on blood parameters in male and female Wistar rats.
| Parameters | Sex | LN18178 Dose (mg/kg·BW) | |||||
|---|---|---|---|---|---|---|---|
| Main groups | Reversal groups | ||||||
| 0 | 625 | 1250 | 2500 | 0 | 2500 | ||
| WBC (103 cells/μL) | M | 9.22 ± 1.43 | 8.17 ± 1.86 | 7.32 ± 1.25∗ | 7.48 ± 1 | 8.42 ± 0.08 | 8.05 ± 1.23 |
| F | 5.41 ± 1.17 | 6.05 ± 1.22 | 5.65 ± 0.89 | 5.15 ± 1.1 | 6.38 ± 1.39 | 6.78 ± 0.84 | |
| Neutrophils (%) | M | 15.15 ± 2.82 | 13.58 ± 5.12 | 13.39 ± 3.76 | 14.69 ± 3.81 | 14.28 ± 0.58 | 15.2 ± 0.56∗ |
| F | 12.14 ± 1.21 | 14.2 ± 5.69 | 14.13 ± 2.81 | 12.35 ± 2.42 | 11.5 ± 2.17 | 13.48 ± 0.55 | |
| Lymphocytes (%) | M | 81.94 ± 2.94 | 83.11 ± 5.87 | 82.07 ± 5.03 | 81.53 ± 3.05 | 82 ± 0.82 | 81.14 ± 1.38 |
| F | 84.73 ± 1.74 | 82.58 ± 6.43 | 82.44 ± 3.35 | 83.2 ± 2.68 | 84.96 ± 1.86 | 82.22 ± 0.96∗ | |
| Monocytes (%) | M | 2.17 ± 1.07 | 2.38 ± 1.02 | 3.21 ± 1.52 | 2.67 ± 1.47 | 2.58 ± 0.43 | 2.58 ± 0.78 |
| F | 2.26 ± 1.04 | 2.3 ± 0.77 | 2.55 ± 1.49 | 3.54 ± 1.45 | 2.5 ± 0.88 | 2.7 ± 0.45 | |
| Eosinophils (%) | M | 0.74 ± 0.37 | 0.93 ± 0.25 | 1.33 ± 0.54∗ | 1.11 ± 0.38 | 1.14 ± 0.23 | 1.08 ± 0.68 |
| F | 0.87 ± 0.33 | 0.92 ± 0.18 | 0.88 ± 0.29 | 0.91 ± 0.34 | 1.04 ± 0.15 | 1.6 ± 0.38∗ | |
| Basophils (%) | M | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| F | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
| RBC (106 cells/μL) | M | 9.39 ± 0.66 | 8.76 ± 0.58∗ | 9.02 ± 0.39 | 9.04 ± 0.44 | 8.79 ± 0.19 | 8.84 ± 0.26 |
| F | 8.49 ± 0.52 | 8.45 ± 0.39 | 8.16 ± 0.37 | 8.14 ± 0.38 | 8.37 ± 0.32 | 7.69 ± 0.67 | |
| Hemoglobin (g/dL) | M | 16.9 ± 0.46 | 16.76 ± 0.71 | 16.71 ± 0.39 | 16.83 ± 0.6 | 16.62 ± 0.16 | 16.3 ± 0.78 |
| F | 15.58 ± 0.52 | 15.8 ± 1.08 | 16.06 ± 0.48 | 15.78 ± 0.4 | 16.28 ± 0.62 | 15.28 ± 0.94 | |
| Hematocrit (%) | M | 50.44 ± 2.09 | 48.95 ± 2.74 | 49.53 ± 1.62 | 49.7 ± 2.28 | 48.76 ± 1.09 | 47.5 ± 2.34 |
| F | 46.9 ± 1.63 | 46.52 ± 2.48 | 47.31 ± 2.32 | 46.81 ± 1.99 | 48.46 ± 1.84 | 44.64 ± 2.51∗ | |
| MCV (fL) | M | 53.9 ± 2.7 | 55.97 ± 2.06 | 54.95 ± 1.69 | 54.99 ± 1.34 | 55.44 ± 0.11 | 53.68 ± 1.52∗ |
| F | 55.43 ± 3.64 | 55.07 ± 3.16 | 58.04 ± 2.59 | 57.55 ± 2.24 | 57.92 ± 0.23 | 58.24 ± 1.74 | |
| MCH (pg) | M | 18.07 ± 0.98 | 19.19 ± 0.8∗ | 18.52 ± 0.47 | 18.63 ± 0.33 | 18.94 ± 0.34 | 18.42 ± 0.66 |
| F | 18.44 ± 1.14 | 18.7 ± 1.37 | 19.72 ± 0.99∗ | 19.42 ± 0.99 | 19.48 ± 0.26 | 19.92 ± 0.44 | |
| MCHC (g/dL) | M | 33.52 ± 0.58 | 34.27 ± 0.63∗ | 33.73 ± 0.64 | 33.9 ± 0.76 | 34.12 ± 0.59 | 34.3 ± 0.52 |
| F | 33.24 ± 0.39 | 33.93 ± 0.62 | 33.99 ± 1.04 | 33.74 ± 1.45 | 33.6 ± 0.42 | 34.2 ± 0.32∗ | |
| Platelets (103 cells/μL) | M | 825.5 ± 114.7 | 758.3 ± 82.6 | 741.7 ± 78.2 | 689.8 ± 50.9∗ | 722.2 ± 15.7 | 808.2 ± 68.6∗ |
| F | 876.9 ± 96.6 | 833.2 ± 71.2 | 828.5 ± 65.5 | 879.8 ± 74.1 | 797 ± 74.2 | 950 ± 34.1∗ | |
| Reticulocytes (%) | M | 1.13 ± 0.22 | 1.35 ± 0.22 | 1.2 ± 0.22 | 1.35 ± 0.23 | 1.2 ± 0.28 | 1.28 ± 0.19 |
| F | 1.2 ± 0.29 | 1.29 ± 0.29 | 1.29 ± 0.31 | 1.36 ± 0.26 | 1.26 ± 0.27 | 1.14 ± 0.21 | |
| Clotting time (sec) | M | 144 ± 23.66 | 150 ± 20 | 159 ± 20.25 | 153 ± 22.14 | 150 ± 21.21 | 156 ± 25.1 |
| F | 147 ± 22.14 | 150 ± 24.49 | 150 ± 20 | 153 ± 26.27 | 132 ± 16.43 | 150 ± 21.21 | |
Data are presented as mean ± SD; ∗ indicates significant changes (p < 0.05) compared with the control group. MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RBC, red blood cells; WBC, white blood cells.