Table 5.
Effect of 90-day oral administration of LN18178 on the absolute and relative organ weights of male Wistar rats.
| Organs | LN18178 dose (mg/kg·BW) | |||||
|---|---|---|---|---|---|---|
| Main groups (n = 10) | Reversal groups (n = 5) | |||||
| 0 | 625 | 1250 | 2500 | 0 | 2500 | |
| Liver (g) | 10.17 ± 1.07 | 9.89 ± 1.22 | 9.93 ± 1.21 | 9.46 ± 1.48 | 11.45 ± 1.42 | 11.39 ± 1.27 |
| % of BW | 2.78 ± 0.39 | 2.65 ± 0.27 | 2.66 ± 0.10 | 2.56 ± 0.23 | 2.83 ± 0.44 | 2.84 ± 0.14 |
| Kidneys (g) | 2.35 ± 0.23 | 2.22 ± 0.29 | 2.31 ± 0.24 | 2.36 ± 0.30 | 2.56 ± 0.32 | 2.69 ± 0.33 |
| % of BW | 0.64 ± 0.05 | 0.60 ± 0.06 | 0.62 ± 0.03 | 0.64 ± 0.06 | 0.63 ± 0.08 | 0.67 ± 0.08 |
| Adrenal glands (g) | 0.06 ± 0.01 | 0.06 ± 0.01 | 0.06 ± 0.01 | 0.06 ± 0.01 | 0.05 ± 0.01 | 0.06 ± 0.00 |
| % of BW | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 |
| Heart (g) | 1.06 ± 0.14 | 1.08 ± 0.10 | 1.11 ± 0.10 | 1.15 ± 0.23 | 1.21 ± 0.10 | 1.17 ± 0.08 |
| % of BW | 0.29 ± 0.02 | 0.29 ± 0.02 | 0.29 ± 0.03 | 0.31 ± 0.05 | 0.30 ± 0.03 | 0.29 ± 0.01 |
| Brain (g) | 2.04 ± 0.09 | 2.00 ± 0.10 | 2.08 ± 0.19 | 2.06 ± 0.12 | 2.01 ± 0.07 | 2.05 ± 0.16 |
| % of BW | 0.56 ± 0.06 | 0.54 ± 0.03 | 0.56 ± 0.04 | 0.56 ± 0.06 | 0.50 ± 0.03 | 0.51 ± 0.05 |
| Spleen (g) | 0.69 ± 0.11 | 0.69 ± 0.08 | 0.64 ± 0.08 | 0.71 ± 0.12 | 0.75 ± 0.05 | 0.72 ± 0.06 |
| % of BW | 0.19 ± 0.05 | 0.19 ± 0.02 | 0.17 ± 0.02 | 0.19 ± 0.03 | 0.19 ± 0.02 | 0.18 ± 0.02 |
| Thymus (g) | 0.42 ± 0.08 | 0.41 ± 0.06 | 0.39 ± 0.07 | 0.44 ± 0.10 | 0.37 ± 0.03 | 0.32 ± 0.05 |
| % of BW | 0.11 ± 0.02 | 0.11 ± 0.01 | 0.10 ± 0.01 | 0.12 ± 0.03 | 0.09 ± 0.01 | 0.08 ± 0.01 |
| Testes (g) | 3.72 ± 0.58 | 3.56 ± 0.30 | 3.70 ± 0.38 | 3.58 ± 0.31 | 3.59 ± 0.18 | 3.77 ± 0.24 |
| % of BW | 1.01 ± 0.14 | 0.96 ± 0.07 | 1.00 ± 0.08 | 1.13 ± 0.50 | 0.89 ± 0.11 | 0.94 ± 0.10 |
| Epididymis (g) | 1.45 ± 0.10 | 1.40 ± 0.12 | 1.45 ± 0.18 | 1.46 ± 0.15 | 1.56 ± 0.14 | 1.68 ± 0.16 |
| % of BW | 0.40 ± 0.04 | 0.38 ± 0.02 | 0.39 ± 0.03 | 0.40 ± 0.03 | 0.39 ± 0.05 | 0.42 ± 0.03 |
| SV-CG and prostate gland (g) | 2.98 ± 0.55 | 2.78 ± 0.35 | 2.87 ± 0.34 | 2.93 ± 0.30 | 2.96 ± 0.30 | 3.05 ± 0.52 |
| % of BW | 0.81 ± 0.11 | 0.75 ± 0.08 | 0.78 ± 0.11 | 0.80 ± 0.08 | 0.73 ± 0.08 | 0.78 ± 0.19 |
| Thyroid with parathyroid (g) | 0.04 ± 0.02 | 0.03 ± 0.01 | 0.02 ± 0.01∗ | 0.02 ± 0.00∗ | 0.05 ± 0.02 | 0.06 ± 0.02 |
| % of BW | 0.01 ± 0.01 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 |
| Pituitary gland (g) | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 |
| % of BW | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
Data are presented as mean ± SD. ∗ indicates significant changes (p < 0.05) compared with the control group. BW, body weight; SV-CG, seminal vesicle and coagulating gland.