Table 7.
Effect of 90-day oral administration of LN18178 on hormones in male and female Wistar rats.
| Measurements | Sex | LN18178 dose (mg/kg·BW) | |||||
|---|---|---|---|---|---|---|---|
| Main groups (n = 20) | Reversal groups (n = 10) | ||||||
| 0 | 625 | 1250 | 2500 | 0 | 2500 | ||
| T3 (ng/mL) | M | 0.42 ± 0.09 | 0.34 ± 0.07 | 0.44 ± 0.10 | 0.40 ± 0.06 | 0.36 ± 0.11 | 0.38 ± 0.15 |
| F | 0.39 ± 0.05 | 0.43 ± 0.09 | 0.33 ± 0.06 | 0.44 ± 0.09 | 0.41 ± 0.07 | 0.44 ± 0.14 | |
| T4 (μg/dL) | M | 4.00 ± 0.60 | 3.62 ± 0.57 | 3.62 ± 0.54 | 4.36 ± 0.73 | 4.20 ± 0.38 | 4.43 ± 0.70 |
| F | 3.11 ± 0.61 | 2.74 ± 0.74 | 3.43 ± 0.77 | 2.99 ± 0.39 | 3.46 ± 0.42 | 3.11 ± 0.32 | |
| TSH (ng/mL) | M | 1.63 ± 0.22 | 1.62 ± 0.24 | 1.57 ± 0.19 | 1.55 ± 0.17 | 1.71 ± 0.33 | 1.62 ± 0.27 |
| F | 1.62 ± 0.19 | 1.62 ± 0.18 | 1.56 ± 0.18 | 1.64 ± 0.26 | 1.70 ± 0.38 | 1.65 ± 0.26 | |
Data are presented as mean ± SD. T3, triiodothyronine; T4, thyroxine; TSH, thyroid-stimulating hormone. Each main group (n = 20; 10 male and 10 female rats); each reversal group (n = 10; 5 male and 5 female rats).