Table 8.
Summary of histopathological changes in the vital organs of the male and female rats after 90-day oral administration of LN18178.
| Organs | Pathological observations | Dose (mg/kg/day BW) | |||
|---|---|---|---|---|---|
| 0 | 2500 | 0 | 2500 | ||
| Male (n = 10) | Female (n = 10) | ||||
| Adrenal glands | Hemorrhage, zona fasciculata | 0 | 0 | 1 (++) | 0 |
| Eyes | Hyperplasia, retina | 0 | 0 | 1 (+) | 0 |
| Folds, retina | 0 | 0 | 0 | 1 (++) | |
| Lungs | Hemorrhage, alveolar | 1 (++) | 1 (+) | 1 (++) | 0 |
| Pigmented macrophage | 0 | 2 (+) | 0 | 0 | |
| Stomach | Increased mucosa-associated lymphoid tissue | 0 | 0 | 1 (+) | 0 |
| Duodenum | Yellow pigment | 0 | 1(+) | 0 | 0 |
| Liver | Necrosis | 1 (++) | 0 | 0 | 0 |
| Kidneys | Lymphocyte infiltrate, cortex | 1 (++) | 1 (++) | 0 | 0 |
| Mesenteric lymph nodes | Pigmented macrophage | 0 | 1 (++) | 0 | 0 |
| Testes | Inflammation | 1 (++) | 1 (++) | — | — |
| Epididymis | Inflammation | 1 (+) | 1 (+++) | — | — |
The scores in parentheses +, ++, and +++ indicates minimal, mild, and marked effects, respectively; BW, body weight.