Fig. 2.

24-h urinary sodium excretion and excretion-derived salt intake of 6–12-year-old DONALD children over 34 years till 2018 (n = 959 children, 4028 urine samples). Salt intake (g/d) was calculated from 24-h sodium excretion through multiplication by the factor 2.5. Time trend for whole period 1985–2018: p < 0.0001, β value 0.022 (0.015, 0.029). Analyses were performed by linear mixed-effects regression models (PROC MIXED). Statistical variance components of the mixed-models are shown in Supplemental Table 1