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. 2022 May 13;5:459. doi: 10.1038/s42003-022-03384-y

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Fig. 2 — a Dihydrofolate reductase (DHFR) converts dihydrofolate (DHF) to tetrahydrofolate (THF) by protonation form solvent and hydride transfer from NADPH. b The structures of clinically relevant DHFR inhibitors and propargyl-linked antifolates, UCP1223 and UCP1228.