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. 2022 Apr 28;9:847136. doi: 10.3389/fnut.2022.847136

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Copyright © 2022 Rahat, Hamid, Bagga and Kaur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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qRT-PCR analysis of DNMTs normalized with GAPDH. (A, B) Relative fold change in DNMT1 mRNA levels, (C, D) relative fold change in DNMT3A mRNA levels (E, F) relative fold change in DNMT3B mRNA levels (A, C, E) among different villi samples (B, D, F) among different placental cells viz JEG-3, HTR-8/Svneo and first trimester villi. The data are expressed as mean fold change ± SEM. FV, SV, TV, and PV -first trimester, second trimester, third trimester, and preeclampsia placental villi samples respectively. [**p < 0.01, ***p < 0.001 with respect to FV, ^###p < 0.001 with respect to SV, ^€€€p < 0.001 with respect to TV], [^‡p < 0.05, ^‡‡p < 0.01, ^‡‡‡p < 0.001 with respect to JEG-3 and ^∧∧∧p < 0.001 with respect to HTR-8/SVneo].