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. 2022 Apr 28;9:847136. doi: 10.3389/fnut.2022.847136

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Copyright © 2022 Rahat, Hamid, Bagga and Kaur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative fold change in mRNA levels of DNMTs upon folic acidsupplementation in JEG-3 and HTR-8/SVneo cells. (A) DNMT1, (B) DNMT3A, and (C) DNMT3B. F0- without folic acid supplementation, F10⁻⁷and F10⁻⁴ - folic acid supplementation at the concentration of F10⁻⁷ and F10⁻⁴ M, respectively. The data are expressed as mean fold change ±SEM of three experiments. *p < 0.05, **p < 0.01, ***p < 0.001 with respect to the respective F0 control and ^##p < 0.01 and ^###p < 0.001 with respect to respective F10-7 treated cells.