Table 3.

Correlation analysis of mRNA expression of various DNMTs, folate level, and global methylation level in HTR-8/SVneo cells upon folic acid supplementation.

	Folate level	Global methylation	LINE1 methylation	DNMT1 mRNA expression	DNMT3A mRNA expression	DNMT3B mRNA expression
Folate level	1	−0.82	0.63	−0.77	−0.83	0.98
Global methylation	−0.82	1	−0.075	0.99*	1.00*	−0.9
LINE1 methylation	0.63	−0.07	1	−0.003	−0.09	0.49
DNMT1 mRNA expression	−0.77	0.99*	−0.003	1	0.99*	−0.87
DNMT3A mRNA expression	−0.83	1.00*	−0.09	0.99*	1	−0.91
DNMT3B mRNA expression	0.98	−0.9	0.49	−0.87	−0.91	1

^*p < 0.05.