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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Br J Pharmacol. 2022 Feb 7;179(12):2953–2968. doi: 10.1111/bph.15779

FIGURE 1.

FIGURE 1.

Effect of fluoxetine and amitriptyline on Kir4.1 and Kir4.1/Kir5.1 currents overexpressed in CHO cells. Summary graphs of homomeric Kir4.1 (a) and heteromeric Kir4.1/Kir5.1 (b) single-channel activity (NPo) after application of PSS as vehicle control, 100 μM fluoxetine (Kir4.1, n = 6; Kir4.1/Kir5.1, n = 8) or 100 μM amitriptyline (Kir4.1, n = 9; Kir4.1/Kir5.1, n =13). Paired sample t-test *P < 0.05. Single-channel closed (c) and open states for the representative recorded currents are indicated by solid and dashed lines. Current-voltage relationships of Kir4.1 (n = 6) and heteromeric Kir4.1/Kir5.1 (n = 6) current are shown in the left panels (linear fitting, instrumental weight. Adj. R-Square ≥0.83).