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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Br J Pharmacol. 2022 Feb 7;179(12):2953–2968. doi: 10.1111/bph.15779

FIGURE 3.

FIGURE 3.

Acute inhibition of Kir4.1/Kir5.1 channel suppresses ENaC single-channel activity in mCCDcl1 cells. Representative traces of ENaC activity recorded in cell-attached mode after application of PSS or DMSO as vehicle control or application of 100 μM amitriptyline (a) or 30 μM VU992 (b). Conformational closed (c) and open states are indicated by solid and dashed lines. Patches were clamped to -Vp = −60 mV. Corresponding summary graphs show that application of 100 μM amitriptyline (n = 7) or 30 μM VU992 (n = 6) induced a decrease in ENaC single-channel activity. Paired sample t-test *P < 0.05.