TABLE 1.

2-year transition probabilities from five state model for cognitive status

Transition			Intensive	Standard	Hazard Ratio
From	To	Overall	Treatment	Treatment	(95% CI)
Normal Cognition	MCI	4.3% (3.9%, 4.9%)	4.1% (3.6%, 4.6%)	4.6% (4.1%, 5.2%)	0.87 (0.79, 0.96)
Normal Cognition	Probable Dementia	0.6% (0.5%, 0.9%)	0.6% (0.3%, 0.9%)	0.6% (0.5%, 0.9%)	1.26 (0.76, 2.09)
Normal Cognition	Death	2.3% (2.0%, 2.7%)	2.2% (1.9%, 2.7%)	2.4% (2.0%, 2.9%)	0.96 (0.73, 1.25)
MCI	Intermittent MCI	31.6% (28.9%, 34.5%)	32.8% (29.1%, 36.4%)	30.5% (27.2%, 34.0%)	1.04 (0.87, 1.25)
MCI	Probable Dementia	5.9% (4.5%, 7.7%)	4.9% (3.4%, 7.0%)	6.9% (5.0%, 9.5%)	0.70 (0.46, 1.07)
MCI	Death	10.0% (8.3%, 11.9%)	9.3% (7.1%, 12.1%)	10.5% (8.3%, 13.3%)	0.88 (0.62, 1.24)
Intermittent MCI	MCI	25.1% (20.7%, 30.2%)	24.4% (18.4%, 31.5%)	25.6% (20.0%, 32.2%)	0.92 (0.59, 1.45)

CI denotes confidence interval and MCI Mild Cognitive Impairment. Estimates are from multistate survival model as shown in FIGURE 1. In SPRINT, 63% of follow-up was during the active intervention phase, the rest consisting of observational follow-up. Above estimates similarly assume 63% of 2-year interval consists of active intervention.