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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Trends Cell Biol. 2022 Jan 7;32(6):513–526. doi: 10.1016/j.tcb.2021.12.003

Figure 5. Leveraging the SASP for cancer therapy.

Figure 5.

The SASP plays a context-dependent role in senescence-inducing cancer therapy. Boosting the SASP is known to promote immune surveillance and clearance of senescent cells. In addition, the SASP enhances immune infiltration to synergize with cancer immunotherapy such as immune checkpoint blockades. In contrast, inhibiting the SASP is beneficial in reducing cancer stemness and preventing therapy relapse.