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. Author manuscript; available in PMC: 2022 Jul 8.
Published in final edited form as: Mol Psychiatry. 2022 Jan 8;27(3):1829–1838. doi: 10.1038/s41380-021-01404-7

Figure 2:

Figure 2:

Effects of optogenetic stimulation of hippocampal terminal fields on anxiety-related behaviors following ChR2 infusion in the medial septum of C57BL/6J mice. AAV2-ChR2 was infused into the MSDBB (A), and an optic fiber was placed above the dorsal hippocampus (B) allowing stimulation of the septo-hippocampal pathway (C). Time spent in the light side of the light-dark box (D). Time spent immobile in the tail suspension test (E). Time to first feeding episode in the novelty-suppressed feeding test (F). Results are expressed as Mean +/− SEM. *: p < 0.05. Control males, n = 9; ChR2 males, n = 9. Control females, n = 7; ChR2 females, n = 6.