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. Author manuscript; available in PMC: 2022 Jul 8.
Published in final edited form as: Mol Psychiatry. 2022 Jan 8;27(3):1829–1838. doi: 10.1038/s41380-021-01404-7

Figure 3:

Figure 3:

Behavioral effects of retrograde infusion of a Cre-dependent DREADD construct into the hippocampus of ChAT-Cre mouse lines. BAC-ChAT-Cre and ChAT-KI-Cre male mice were infused with a Gq-DREADD-carrying retrograde virus into the hippocampus (A) allowing activation of hippocampal cholinergic projections (with CNO 10 mg/kg) (B). Time spent in the light side of the light-dark box (BAC-ChAT-Cre (C), ChAT-KI-Cre (G)). Time spent immobile in the tail suspension test (BAC-ChAT-Cre (D), ChAT-KI-Cre (H)) or forced swim test (BAC-ChAT-Cre (E), ChAT-KI-Cre (I)). Ratio of interaction (time with CD1/time without CD1) following 8 social defeats (BAC-ChAT-Cre (F), ChaT-KI-Cre (J)). Results are expressed as Mean +/− SEM. *: p < 0.05; **: p < 0.01; ***: p < 0.001. BAC-Chat-Cre: Control, n = 9; Gq, n = 9. ChAT-KI-Cre: Control, n = 9; Gq, n = 10.