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. Author manuscript; available in PMC: 2022 Jul 20.
Published in final edited form as: Mol Psychiatry. 2022 Jan 20;27(3):1515–1526. doi: 10.1038/s41380-021-01424-3

Figure 2. Amphetamine reveals increased basal ganglia-dependent repetitive behavior in Slc1a1-Th-OE mice.

Figure 2.

(A) Experimental timeline. For all panels, n = 8 control, 11 Th-OE mice. No genotype differences were found in basal locomotion in saline-injected Th-OE and control mice in a familiar environment (B, third order polynomial least squares fit, t = 0–60; F (4, 334) = 1.349, P = 0.2515). Th-OE mice show significantly increased locomotor response to (B) low and (C) moderate doses of AMPH. (D) Th-OE mice display increased stereotypic behavior following 8.0 mg/kg AMPH dose. (E) SKF-38393-induced grooming response is not altered in Th-OE mice. ****P < 0.0001; nsP, not significant. Also see Supplementary Figures S3, S4 for baseline anxiety-like and repetitive behaviors and Supplementary Figures S5, S6 for tet-operator and tTA transgene control experiments.