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. Author manuscript; available in PMC: 2023 Jun 15.
Published in final edited form as: J Neuroimmunol. 2022 Mar 31;367:577859. doi: 10.1016/j.jneuroim.2022.577859

Figure 4. Microglia were activated in the inner retina of OSE mice.

Figure 4.

a) Representative images of microglia staining in the inner retina of OSE mice using anti-IBA1 antibody. b) Quantification of IBA1 expression in the IPL layer of OSE retinas (F=20.28, p<0.0001. For 8-week: Naïve vs BCRMOG, P=0.5154; Naïve vs OSE, P<0.0001; BCRMOG vs OSE, P=0.0005. For 10-week: Naïve vs BCRMOG, P=0.5606; Naïve vs OSE, P<0.0001; BCRMOG vs OSE, P<0.0001). c). Quantification of IBA1 expression in the OPL layer of OSE retinas (F=35.65, p<0.0001. For 8-week: Naïve vs BCRMOG, P=0.0994; Naïve vs OSE, P<0.0001; BCRMOG vs OSE, P<0.0001. For 10-week: Naïve vs BCRMOG, P=0.5105; Naïve vs OSE, P<0.0001; BCRMOG vs OSE, P<0.0001). Each dot from bar graph represents one mouse. Significance of IBA1 level between groups was assessed by one-way ANOVA (* P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001, N.S. = no significance). Error bars represent SEM. Scale bar =50μm.