. Author manuscript; available in PMC: 2023 Jun 1.

Published in final edited form as: Ann Neurol. 2022 Mar 30;91(6):864–877. doi: 10.1002/ana.26353

Table 3.

Partial Correlation Coefficients of the Associations Between Cognitive Domain Factor Scores and Imaging Biomarkers with Metric Values of the Voxelwise Regions of Interest (N = 153).

	FA	MD	AWF	D _e,⊥
A. AD-Relevant Cognitive Domains
Memory factor	−0.02	−0.00	−0.14	−0.01
Language factor	0.04	0.01	−0.09	0.06
Speed/Executive Functions factor	0.11	−0.08	0.18^*	−0.02
B. Imaging Biomarkers
Amyloidosis
mSUVr^a	0.28^**	−0.28^**	0.16	−0.28^**
Neurodegeneration
AD Signature	0.22^**	−0.23^**	0.18^*	−0.15
Global atrophy	0.21^**	−0.05	0.17^*	−0.06
Hippocampal volume	0.14	−0.08	0.20^*	−0.07
White matter hyperintensities
Lesion volume	−0.24^**	0.20^*	−0.13	0.31^**

Note: Partial correlations controlled for age, sex, and amyloid status.

Covariates were age and sex.

mSUVr = Mean standardized uptake value ratio.

p < 0.05,

^**

p < 0.01.