Figure 6.

Decoy vesicles confer widespread inhibition of emerging SARS‐CoV‐2 Spike variants. Left: Dose‐response curves depicting the inhibition of various strains of SARS‐CoV‐2 Spike pseudotyped lentivirus by WT‐ACE2 UC‐EVs. The parental strain is the D614G Spike‐lenti. Curves are normalized to the percent of cells transduced at the lowest EV dose in a particular curve. Symbols represent the mean of three biological replicates; error bars are standard error of the mean. Data are representative of two independent experiments. Right: Log(ID₅₀) values calculated from the dose response curves. Numbers above each point report the relative resistance for a given strain relative to the parental strain (D614G). Error bars represent 99% confidence intervals for the parameter (ID₅₀) estimation.