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The fundamental role of CMC in the in vivo efficacy and systemic toxicity of self-assembling prodrugs (SAPDs). Illustration of the circulation fate of a SAPD after entering into the circulation, indicates that the lower the CMC of a SP, the lower the percentage of fragments and monomers, leading to reduced excretion and enhanced tumor (improved efficacy) and healthy organ uptake (increased toxicity). Adapted from [38].
