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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Trends Pharmacol Sci. 2022 Apr 19;43(6):510–521. doi: 10.1016/j.tips.2022.03.003

Figure 4.

Figure 4.

Peptide-based self-assembling prodrugs for enhanced therapeutic. (a) The in situ formed supramolecular hydrogel made of diCPT-PLGLAG-iRGD nanofilaments locally delivered camptothecin and aPD1 as an immune booster for immune checkpoint blockade therapy. Adapted from [78]. (b) Illustration of the spherical nanostructures formed by the self-assembling zwitterionic polypeptide (ZIPP) Paclitaxel conjugates. The ZIPP-PTX nanoparticles increased circulation time and outperformed Abraxane in multiple tumor models. Adapted from [83]; 2020 American Chemical Society.