Table 2. Pharmacokinetically obtained parameters from the in vivostudy of the released drug in rabbit’s tear after drop instillation of 50 μL of AZM solution or AZM nanofibers with different formulations (mean ± SD, n = 6) .
Formulation | Cmax (μg/mL) | AUC 0-t (μg h/mL) | MRT (h) |
FZ-A | 2483.31 ± 46.30 | 24504.38 ± 28.62 | 17.97 ± 2.18 |
FZ-P | 2759.59 ± 51.45 | 35462.96 ± 154.76 | 15.74 ± 0.11 |
FZ-AG | 1269.19 ± 94.58 | 14688.09 ± 95.10 | 24.07 ± 1.28 |
FZ-PG | 1607.52 ± 59.94 | 15145.16 ± 150.32 | 26.73 ± 2.11 |
AZM solution | 583.42 ± 54.32 | 2871.24 ± 143.03 | 4.22 ± 0.20 |