Table 2.
Continuous variables.
| Variable name | Units | Entire cohort median (IQR) | Mild MIS-C median (IQR) | Severe MIS-C median (IQR) | p value |
|---|---|---|---|---|---|
| Cardiac markers | |||||
| Lactate | mmol/L | 1.60 (1.50–1.62) | 1.60 (1.60–1.60) | 1.80 (1.30–2.90) | 0.016 |
| BNP | pg/mL | 132.70 (42.08–400.05) | 67.80 (28.35–232.60) | 349.00 (115.90–851.50) | <0.001 |
| Troponin | ng/mL | 0.02 (0.01–0.12) | 0.01 (0.01–0.05) | 0.09 (0.01–0.42) | <0.001 |
| LVEF | % | 59.00 (50.75–64.06) | 62.09 (56.00–65.04) | 53.00 (44.00–60.95) | <0.001 |
| Inflammatory/infection markers | |||||
| C-reactive protein | mg/dL | 18.05 (11.25–24.20) | 15.90 (7.80–21.15) | 22.70 (15.50–29.10) | <0.001 |
| Ferritin | ng/mL | 303.00 (176.50–606.25) | 207.00 (125.50–399.50) | 457.00 (271.00–782.00) | <0.001 |
| Fibrinogen | mg/dL | 559.50 (504.75–672.75) | 551.00 (506.00–623.00) | 583.00 (501.00–719.00) | 0.120 |
| Lymph | 103/µL | 1.02 (0.69–1.65) | 1.02 (0.73–1.75) | 0.95 (0.67–1.47) | 0.390 |
| Procalcitonin | ng/mL | 3.94 (1.55–11.36) | 2.25 (1.13–6.99) | 8.07 (3.29–26.45) | <0.001 |
| Segmented neut | % | 81.40 (74.28–86.15) | 80.40 (69.20–83.30) | 84.70 (79.30–88.30) | <0.001 |
| WBC | 103/µL | 9.49 (7.21–12.43) | 8.08 (6.09–11.14) | 11.41 (9.13–13.84) | <0.001 |
| Coagulation markers | |||||
| Platelets count | 103/µL | 158.00 (113.75–208.25) | 173.00 (132.50–230.50) | 140.00 (102.00–191.00) | 0.009 |
| D dimer | µg/mL | 3.21 (2.12–4.81) | 2.84 (1.92–4.14) | 3.63 (2.68–5.66) | 0.004 |
| PTT | s | 33.10 (31.07–36.65) | 33.10 (31.50–34.35) | 33.30 (29.40–39.00) | 0.296 |
| INR | 1.20 (1.20–1.30) | 1.20 (1.10–1.20) | 1.30 (1.20–1.40) | <0.001 | |
| Protime | s | 15.60 (14.97–16.50) | 15.60 (14.35–15.60) | 16.00 (15.30–17.20) | <0.001 |
| Thrombin time | s | 15.50 (14.95–15.90) | 15.50 (15.40–16.20) | 15.30 (14.50–15.90) | 0.021 |
| Renal markers | |||||
| Sodium | mmol/L | 133.00 (130.00–135.00) | 133.00 (131.00–135.00) | 132.00 (129.00–134.00) | 0.055 |
| Potassium | mmol/L | 3.90 (3.60–4.22) | 4.00 (3.70–4.30) | 3.70 (3.40–4.10) | <0.001 |
| Magnesium | mg/dL | 2.10 (2.00–2.30) | 2.10 (2.00–2.30) | 2.10 (2.00–2.40) | 0.736 |
| Phosphorus | mg/dL | 3.60 (3.20–4.10) | 3.70 (3.35–4.10) | 3.50 (2.90–4.00) | 0.077 |
| Ionized calcium | mmol/L | 1.16 (1.15–1.17) | 1.16 (1.15–1.17) | 1.16 (1.10–1.20) | 0.407 |
| BUN | mg/dL | 13.00 (10.00–20.00) | 12.00 (9.50–13.50) | 18.00 (13.00–28.00) | <0.001 |
| Creatinine | mg/dL | 0.47 (0.34–0.79) | 0.38 (0.31–0.54) | 0.73 (0.46–1.18) | <0.001 |
| GI/liver markers | |||||
| AST | U/L | 56.00 (41.00–77.25) | 52.00 (40.00–71.50) | 59.00 (44.00–84.00) | 0.091 |
| ALT | U/L | 37.00 (24.00–60.25) | 30.00 (22.00–50.00) | 43.00 (26.00–67.00) | 0.018 |
| GGT | U/L | 42.00 (31.00–62.75) | 42.00 (25.00–42.00) | 51.00 (37.00–89.00) | <0.001 |
| Alkaline phosphatase | U/L | 138.00 (107.75–162.25) | 138.00 (108.50–151.00) | 139.00 (104.00–166.00) | 0.485 |
| Albumin | g/dL | 3.50 (3.10–3.82) | 3.60 (3.30–3.90) | 3.20 (2.90–3.70) | <0.001 |
| Hematological markers | |||||
| HGB | g/dL | 11.20 (10.38–12.30) | 11.20 (10.30–12.10) | 11.30 (10.50–12.30) | 0.718 |
| HCT | % | 33.15 (31.00–35.88) | 33.10 (31.20–35.75) | 33.20 (30.50–36.50) | 0.933 |
| RBC | 106/µL | 4.13 (3.83–4.49) | 4.14 (3.85–4.50) | 4.09 (3.78–4.49) | 0.685 |
| MCH | pg | 27.40 (26.27–28.60) | 27.30 (26.05–28.45) | 27.50 (26.70–28.70) | 0.186 |
| MCV | fL | 80.80 (78.50–82.95) | 80.70 (78.20–82.90) | 80.90 (79.00–83.10) | 0.630 |
| MCHC | g/dL | 33.90 (33.10–34.70) | 33.90 (33.00–34.60) | 34.00 (33.30–35.10) | 0.160 |
| Vital signs | |||||
| HR | z score | 1.88 (1.37–2.71) | 1.67 (1.19–2.28) | 2.18 (1.68–2.81) | 0.016 |
| RR | z score | 1.89 (0.83–3.91) | 1.34 (0.36–2.09) | 3.18 (1.30–5.04) | <0.001 |
| mBP | z score | –0.56 (–1.25 to 0.12) | –0.11 (–0.65 to 0.98) | –0.98 (–1.57 to –0.37) | <0.001 |
| sBP | z score | –0.81 (–1.48 to 0.17) | –0.24 (–0.97 to 0.88) | –1.32 (–1.94 to –0.64) | <0.001 |
| dBP | z score | –0.74 (–1.17 to 0.14) | –0.18 (–0.73 to 0.91) | –1.01 (–1.47 to –0.60) | <0.001 |
| Continuous demographics | |||||
| Age | years | 9.17 (4.89–13.09) | 7.74 (3.67–11.28) | 10.27 (8.32–14.40) | <0.001 |
| BMI | z score | 0.87 (–0.03 to 1.71) | 0.58 (–0.18 to 1.42) | 1.44 (0.44–2.13) | 0.002 |
First laboratory results and first-registered vital signs upon admission for the entire cohort, and for the mild and severe MIS-C groups. Vital signs and BMI were transformed to z scores using age- and sex-adjusted mean and standard deviation from the general population. The p values were computed using the non-parametric two-sided Wilcoxon rank-sum method to compare the mild MIS-C and severe MIS-C groups.