Table 2.
Mixed models for ISIa from baseline to week 5 and for weekly sleep diary and KSSb scores from the beginning of the treatment (week 1) to the end of the treatment (week 5).
|
|
Estimate (SE; 95% CI) | P value | |||
| ISI | |||||
|
|
Intercept (AICc 1414.2) | 19.66 (0.70; 18.2 to 21.0) | <.001 d | ||
|
|
Treatment | 1.14 (0.94; −0.69 to 2.98) | .22 | ||
|
|
Time (week 5) | −1.02 (0.23; −1.47 to −0.55) | <.001 | ||
|
|
Time (week 5)×treatment | −0.72 (0.31; −1.33 to −0.11) | .02 | ||
| Sleep onset latency | |||||
|
|
Intercept (AIC 2022.4) | 53.03 (7.37; 38.5 to 67.4) | <.001 | ||
|
|
Treatment | −9.52 (9.62; −28.1 to 9.60) | .34 | ||
|
|
Time (week 5) | 0.68 (5.00; −9.13 to 10.4) | .89 | ||
|
|
TimeQe (week 5) | −0.58 (0.88; −2.32 to 1.14) | .50 | ||
|
|
Time (week 5)×treatment | −13.77 (6.55; −26.5 to −0.09) | .04 | ||
|
|
TimeQ (week 5)×treatment | 2.38 (1.15; 0.13 to 4.63) | .04 | ||
| Wake time after sleep onset | |||||
|
|
Intercept (AIC 1957.3) | 73.24 (17.59; 38.7 to 107.7) | <.001 | ||
|
|
Treatment | −2.27 (18.77; −39.0 to 34.5) | .90 | ||
|
|
Time (week 5) | −5.23 (4.57; −14.4 to 3.43) | .24 | ||
|
|
TimeQ (week 5) | 0.29 (0.41; −0.50 to 1.09) | .47 | ||
|
|
Time (week 5)×treatment | −20.98 (5.96; −32.6 to −9.30) | <.001 | ||
|
|
TimeQ (week 5)×treatment | 4.45 (0.53; 0.53 to 3.41) | <.001 | ||
| Total sleep time | |||||
|
|
Intercept (AIC 2239.3) | 336.75 (20.93; 295.7 to 377.7) | <.001 | ||
|
|
Treatment | 1.37 (27.30; −52.1 to 54.9) | .96 | ||
|
|
Time (week 5) | 5.77 (3.57; −1.22 to 12.7) | .11 | ||
|
|
Time (week 5)×treatment | −0.92 (4.67; −10.1 to 8.23) | .84 | ||
| Sleep efficiency | |||||
|
|
Intercept (AIC 1500.6) | 63.49 (3.71; 56.2 to 70.7) | <.001 | ||
|
|
Treatment | 0.79 (4.46; −7.96 to 9.55) | .86 | ||
|
|
Time (week 5) | 1.34 (0.90; −0.43 to 3.12) | .14 | ||
|
|
TimeQ (week 5) | 0.03 (0.16; −0.27 to 0.35) | .81 | ||
|
|
Time (week 5)×treatment | 8.29 (0.18; 5.97 to 10.6) | <.001 | ||
|
|
TimeQ (week 5)×treatment | −1.44 (0.20; −1.85 to −1.03) | <.001 | ||
| Early morning awakenings | |||||
|
|
Intercept (AIC 1834.3) | 30.40 (6.18; 18.3 to 42.5) | <.001 | ||
|
|
Treatment | 9.80 (8.53; −6.91 to 26.5) | .26 | ||
|
|
Time (week 5) | 0.36 (2.16; −3.87 to 4.58) | .87 | ||
|
|
TimeQ (week 5) | −0.93 (0.35; −1.63 to −0.25) | .008 | ||
|
|
Time (week 5)×treatment | −20.65 (2.82; −26.1 to −15.2) | <.001 | ||
|
|
TimeQ (week 5)×treatment | 4.50 (0.46; 3.60 to 5.41) | <.001 | ||
| KSS | |||||
|
|
Intercept (AIC 585.8) | 6.15 (0.21; 5.73 to 6.56) | <.001 | ||
|
|
Treatment | −0.07 (0.28; −0.49 to 0.62) | .82 | ||
|
|
Time (week 5) | −0.18 (0.06; −0.29 to −0.07) | .002 | ||
|
|
Time (week 5)×treatment | 0.07 (0.07; −0.07 to 0.21) | .33 | ||
aISI: Insomnia Severity Index.
bKSS: Karolinska Sleepiness Scale.
cAIC: Akaike information criterion.
dItalics indicates statistically significant results.
eTimeQ: time quadratic.