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. Author manuscript; available in PMC: 2022 Aug 16.
Published in final edited form as: Nat Struct Mol Biol. 2022 Feb 16;29(2):121–129. doi: 10.1038/s41594-021-00719-x

Figure 1. Structure of the Chd1 remodeler bound to a nucleosome in the nucleotide-free state.

Figure 1.

a, Three views of a cryo-EM reconstruction of the Chd1-nucleosome complex at 2.3 Å resolution. b, Three additional cryo-EM reconstructions from the same dataset: a subclassification focused on the Chd1 DNA-binding domain at 2.7 Å resolution, and two nucleosome-focused subclassifications with and without the ChEx segment at 2.9 Å and 2.6 Å resolution, respectively. c, A composite model of Chd1 bound to the unwrapped nucleosome (PDB code: 7TN2), built using high-resolution and DNA-binding domain subclassification maps. See also Extended Data Fig. 1-4 and Supplementary Video 1.