Table 2.
Characteristics of Indigenous-Australian trials compared to general Australian trials
| Indigenous Australian trials n (%) |
General Australian trials n (%) |
|
|---|---|---|
| Total number of trials | 139 | 9067 |
| Size | ||
| Total number of participants | 155,694 | 2,561,337a |
| Median sample size | 250 (IQR 100–535) | 60 (IQR30–140) |
| Public Health Involvement | ||
| Public Health-related | 59 (42%) | 958 (11%) |
| Non-public health related | 80 (58%) | 8109 (89%) |
| Allocation | ||
| Randomised | 97 (70%) | 6666 (74%) |
| Non-randomised | 41 (30%) | 2148 (24%) |
| Missing | 1 (0%) | 253 (3%) |
| Masking | ||
| Blinded | 48 (35%) | 4273 (47%) |
| Open | 76 (55%) | 3935 (43%) |
| Missing | 15 (10%) | 859 (9%) |
| Intervention typesb | ||
| Treatment: any | 72 (52%) | 6785 (75%) |
| Prevention | 48 (36%) | 1343 (15%) |
| Behaviour | 41 (30%) | 1542 (17%) |
| Treatment: Other | 35 (26%) | 2465 (27%) |
| Lifestyle | 26 (19%) | 1016 (11%) |
| Treatment: Drugs | 23 (17%) | 2689 (30%) |
| Early detection / Screening | 18 (13%) | 298 (3%) |
| Other interventions | 15 (11%) | 618 (7%) |
| Treatment: Devices | 7 (5%) | 1270 (14%) |
| Treatment: Surgery | 7 (5%) | 361 (4%) |
| Rehabilitation | 5 (4%) | 728 (8%) |
| Diagnosis / Prognosis | 3 (2%) | 289 (3%) |
| Not applicable | 0 (0%) | 3 (0%) |
| Primary Sponsorc | ||
| University | 72 (53%) | 2699 (33%) |
| Individual | 16 (12%) | 1882 (23%) |
| Government body | 14 (10%) | 315 (4%) |
| Other | 13 (10%) | 249 (3%) |
| Charities/Societies/Foundations | 8 (6%) | 272 (3%) |
| Other Collaborative groups | 6 (4%) | 227 (3%) |
| Hospital | 3 (2%) | 1619 (20%) |
| Commercial sector/Industry | 3 (2%) | 868 (11%) |
| Fundingd | ||
| Government body | 107 (79%) | 1930 (21%) |
| Charities/Societies/Foundations | 19 (14%) | 1542 (17%) |
| University | 11 (8%) | 1678 (18%) |
| Commercial sector/Industry | 9 (7%) | 1587 (17%) |
| Other Collaborative groups | 7 (5%) | 295 (3%) |
| Hospital | 6 (4%) | 1238 (13%) |
| Other | 3 (2%) | 241 (3%) |
| Self-funded/Unfunded | 2 (1%) | 759 (8%) |
a Two outliers were eliminated, each with participant size > 100,000 to avoid skewing of results and minimise misinterpretation of the mean recruitment size between Indigenous and General Australian trials
b Percentage calculations were adjusted by the total number of trials, not the number of entries for intervention as each trial could list up to three intervention codes
c Used ANZCTR data only, as CTgov had no data field for sponsorship
d Used ANZCTR data only, as CTgov had fewer categories that could skew results. Each study could list up to 20 entries