Table 5.
Network MR results for the causal pathways
| Causal pairs among different omics | β | Se | P value | ||
|---|---|---|---|---|---|
| Metabolomic → Transcriptomic → Epigenomic | |||||
| Isobutyrylcarnitine | ANO6 | 6.110721178 | − 3.486E−05 | 1.555E−05 | 0.012 |
| Plasmenyl-LysoPE | ANO6 | 6.110721178 | − 0.007 | 0.003 | 0.013 |
| 3-(2-Hydroxyphenyl) Propanoate | ANO6 | 6.110721178 | − 3.811E−05 | 2.146E−05 | 0.038 |
| Ursodeoxycholic Acid (UDCA) | ANO6 | 6.110721178 | − 7E−4 | 3E−04 | 0.013 |
| Isobutyrylcarnitine | CLU | 9.13713161 | − 3.04E−07 | 1.730E−07 | 0.040 |
| Plasmenyl-LysoPE | CLU | 9.13713161 | − 2E−05 | 1E−5 | 0.023 |
| Indole-3acetate | MPEG1 | 6.163743051 | − 9.1E−06 | 4.360E−06 | 0.018 |
| 3-(2-Hydroxyphenyl) Propanoate | MPEG1 | 6.163743051 | − 6.5E−07 | 3.155E−07 | 0.020 |
| Metabolomic → Epigenomic → Transcriptomic | |||||
| UDCA | 6.163743051 | ANO6 | − 2.185E−4 | 9.377E−05 | 0.010 |
| Glucosamine | 6.163743051 | ANO6 | − 2.951E−05 | 1.650E−05 | 0.037 |
| Glucosamine | 6.110721139 | PTGS1 | − 6.491E−05 | 3.219E−05 | 0.022 |
| 3-(2-Hydroxyphenyl) Propanoate | 6.110721139 | PTGS1 | − 1.774E−05 | 9.524E−06 | 0.031 |
| Transcriptomic → Metabolomic → Epigenomic | |||||
| CLU | Aspartate | 9.13713161 | 8.439E−4 | 4.23E−4 | 0.023 |
| CLU | N-Acetylneuraminate | 9.13713161 | − 3.87E−4 | 2.0E−4 | 0.031 |
| MPEG1 | Phenylalanyl-Threonine | 6.163743051 | − 6.41E−4 | 3.61E−4 | 0.038 |
| UGGT1 | N-methyl-D-asparticacid | 6.110721154 | − 2.29E−4 | 1.33E−4 | 0.042 |
| UGGT1 | UDCA | 6.110721178 | − 1.60E−4 | 6.914E−05 | 0.010 |
| UGGT1 | UDCA | 6.110721154 | − 1.00E−4 | 4.77E−05 | 0.018 |