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Schematic representation of the erythropoietin (EPO), erythroferrone (ERFE), hepcidin, ferroportin (Fpn) axis, as it pertains to the regulation of intestinal iron absorption. High EPO levels (1) stimulate erythroblasts to produce ERFE (2). High ERFE levels reduce hepcidin production in the liver (3). Low hepcidin levels facilitate absorption of enteral iron through ferroportin (4). Modified from Ganz et al. [23].
