Table 1.
Characteristics of patients
| Hospital-onset sepsis (n = 52,183) | Community-onset sepsis (n = 463,940) | |
|---|---|---|
| Female sex | 18,812 (36.1) | 190,917 (41.2) |
| Age (year) | 72 [63–79] | 77 [66–84] |
| Weight (kg) | 54.0 [45.6–63.2] | 51.7 [42.0–61.6] |
| Body mass index (kg/m2) | 21.6 [18.9–24.5] | 21.5 [18.6–24.6] |
| Emergency hospitalization | 29,134 (55.9) | 416,535 (89.9) |
| Elixhauser index | 5 [2–11] | 4 [0–7] |
| Surgery under general anesthesia during hospitalization | 25,568 (49.0) | 85,070 (18.3) |
| Days from hospitalization to critical care unit admission, days | 10 [5–22] | 1 [1–1] |
| Types of critical care unit | ||
| Intensive care unit | 41,460 (79.5) | 120,621 (26.0) |
| High dependency unit | 10,485 (20.1) | 83,257 (17.9) |
| Emergency intensive care unit | 238 (0.5) | 260,062 (56.1) |
| Organ support on the day of critical care unit admission | ||
| Vasopressor | 23,123 (44.3) | 110,376 (23.8) |
| Mechanical ventilation | 18,906 (36.2) | 95,165 (20.5) |
| Renal replacement therapy | 7510 (14.4) | 25,479 (5.5) |
| Infusion fluid volume on the 1–2 days of critical care unit, ml | 7620 [3600–15,430] | 3800 [1660–8400] |
| Focus of infection* | ||
| Respiratory | 17,251 (33.1) | 212,922 (45.9) |
| Abdominal | 16,837 (32.3) | 116,011 (25.0) |
| Urogenital | 2004 (3.8) | 50,600 (10.9) |
| CNS | 1946 (3.7) | 27,072 (5.8) |
| Cardiovascular | 4771 (9.1) | 26,607 (5.7) |
| Blood | 3889 (7.5) | 21,565 (4.6) |
| Bone and soft tissue | 2205 (4.2) | 21,641 (4.7) |
| Others | 27,293 (52.3) | 202,967 (43.7) |
Data are presented as n (%) or median [IQR]. The medical codes of critical care units, vasopressor, mechanical ventilation, and renal replacement therapy are described separately (Additional file 1: Appendix 1–7)
*In cases where multiple ICD-10 codes were registered, all of them were counted as the focus of infection