Table 2.
Distribution of CA125 measurements by candidate correlating factors across four quantile ranges (Q1 = [0.7300, 7.6575], Q2 = [7.6575, 11.6050], Q3 = [11.6050, 18.7750], Q4 = [18.7750, 569.37] U/ml)
| Variables | Q1 CA125 (N = 619) | Q2 CA125 (N = 619) | Q3 CA125 (N = 619) | Q4 CA125 (N = 618) | Overall (N = 2476) |
|---|---|---|---|---|---|
| Race/Ethnicity | |||||
| Non-Hispanic White | 293 (47.3%) | 313 (50.6%) | 331 (53.5%) | 370 (59.9%) | 1307 (52.8%) |
| Non-Hispanic Black | 156 (25.2%) | 116 (18.7%) | 87 (14.1%) | 89 (14.4%) | 448 (18.1%) |
| Mexican American | 114 (18.4%) | 143 (23.1%) | 149 (24.1%) | 112 (18.1%) | 518 (20.9%) |
| Other Hispanic | 37 (6.0%) | 19 (3.1%) | 25 (4.0%) | 26 (4.2%) | 108 (4.4%) |
| Other | 19 (3.1%) | 28 (4.5%) | 27 (4.4%) | 21 (3.4%) | 95 (3.8%) |
| Age (years) | |||||
| Mean (SD) | 52.9 (18.2) | 49.2 (19.1) | 46.2 (19.3) | 44.1 (19.4) | 48.1 (19.3) |
| Median [Min, Max] | 53.0 [20.0, 85.0] | 49.0 [20.0, 85.0] | 42.0 [20.0, 85.0] | 38.0 [20.0, 85.0] | 45.0 [20.0, 85.0] |
| BMI (kg/m2) | |||||
| Mean (SD) | 29.1 (7.32) | 28.8 (6.67) | 28.2 (6.61) | 27.7 (6.46) | 28.5 (6.79) |
| Median [Min, Max] | 27.6 [15.8, 65.4] | 27.7 [16.2, 55.4] | 27.3 [17.0, 59.9] | 26.5 [16.4, 61.7] | 27.3 [15.8, 65.4] |
| Smoking history | |||||
| Non-smoker | 361 (58.3%) | 391 (63.2%) | 384 (62.0%) | 378 (61.2%) | 1514 (61.1%) |
| Former smoker | 132 (21.3%) | 113 (18.3%) | 136 (22.0%) | 126 (20.4%) | 508 (20.5%) |
| Current smoker | 126 (20.4%) | 115 (18.6%) | 99 (16.0%) | 114 (18.4%) | 454 (18.3%) |
| Alcohol use history | |||||
| Non-drinking | 198 (37.8%) | 206 (38.7%) | 205 (38.5%) | 195 (37.7%) | 805 (38.2%) |
| One-two drinks per day | 252 (48.1%) | 243 (45.7%) | 250 (47.0%) | 242 (46.7%) | 987 (46.8%) |
| More than two drinks per day | 74 (14.1%) | 83 (15.6%) | 77 (14.5%) | 81 (15.6%) | 315 (15.0%) |
| Daily caffeine intake (mg) | |||||
| Mean (SD) | 133 (178) | 125 (157) | 119 (153) | 124 (155) | 125 (161) |
| Median [Min, Max] | 83.0 [0.00, 1920] | 77.0 [0.00, 1140] | 72.0 [0.00, 1490] | 74.0 [0.00, 1190] | 77.0 [0.00, 1920] |
| Age at menarche (years) | |||||
| ≤ 12 | 267 (47.8%) | 266 (48.3%) | 250 (44.2%) | 253 (47.0%) | 1036 (47.8%) |
| > 12 | 292 (52.2%) | 285 (51.7%) | 315 (55.8%) | 285 (53.0%) | 1178 (53.2%) |
| Parity | |||||
| None | 16 (3.2%) | 11 (2.3%) | 32 (6.5%) | 21 (4.4%) | 80 (4.1%) |
| One | 76 (15.4%) | 86 (17.8%) | 108 (21.9%) | 113 (23.7%) | 383 (19.7%) |
| Two | 143 (29.0%) | 133 (27.5%) | 127 (25.7%) | 150 (31.5%) | 553 (28.4%) |
| Three | 103 (20.9%) | 125 (25.8%) | 107 (21.7%) | 105 (22.1%) | 440 (22.6%) |
| Four or more | 155 (31.4%) | 129 (26.7%) | 120 (24.3%) | 87 (18.3%) | 492 (25.3%) |
| Breastfeeding history | |||||
| No | 205 (43.6%) | 180 (39.1%) | 165 (36.7%) | 161 (36.9%) | 711 (39.1%) |
| Yes | 265 (56.4%) | 280 (60.9%) | 285 (63.3%) | 275 (63.1%) | 1106 (60.9%) |
| Menopause | |||||
| No | 203 (35.6%) | 252 (44.3%) | 338 (58.6%) | 364 (65.6%) | 1157 (50.9%) |
| Yes | 368 (64.4%) | 317 (55.7%) | 239 (41.4%) | 191 (34.4%) | 1116 (49.1%) |
| Duration of oral contraceptive use (years) | |||||
| Less than 2 years | 172 (49.3%) | 154 (44.8%) | 144 (41.1%) | 153 (42.5%) | 623 (44.4%) |
| 2–5 years | 71 (20.3%) | 72 (20.9%) | 80 (22.9%) | 99 (27.5%) | 322 (23.0%) |
| 5–10 years | 68 (19.5%) | 72 (20.9%) | 82 (23.4%) | 74 (20.6%) | 296 (21.1%) |
| More than 10 years | 38 (10.9%) | 46 (13.4%) | 44 (12.6%) | 34 (9.4%) | 162 (11.5%) |
| Current hormonal contraception use | |||||
| No | 18 (25.7%) | 15 (23.4%) | 22 (31.4%) | 16 (34.8%) | 71 (28.4%) |
| Yes | 52 (74.3%) | 49 (76.6%) | 48 (68.6%) | 30 (65.2%) | 179 (71.6%) |
| Current hormone replacement therapy | |||||
| No | 521 (84.2%) | 522 (84.3%) | 558 (90.1%) | 570 (92.2%) | 2172 (87.7%) |
| Yes | 98 (15.8%) | 97 (15.7%) | 61 (9.9%) | 48 (7.8%) | 304 (12.3%) |
| C reactive protein level (mg/dL) | |||||
| Mean (SD) | 0.540 (0.888) | 0.554 (0.824) | 0.549 (1.030) | 0.622 (1.090) | 0.566 (0.962) |
| Median [Min, Max] | 0.290 [0.010, 14.0] | 0.290 [0.010, 10.7] | 0.280 [0.010, 18.5] | 0.330 [0.010, 16.3] | 0.300 [0.010, 18.5] |
| Ferritin level (ng/mL) | |||||
| Mean (SD) | 93.5 (107) | 79.1 (99.6) | 66.7 (87.2) | 67.9 (99.1) | 77.0 (99.8) |
| Median [Min, Max] | 61.0 [3.0, 1040] | 47.0 [3.0, 1230] | 39.0 [3.0, 933] | 33.0 [3.0, 981] | 44.0 [3.0, 1230] |
| History of hysterectomy | |||||
| No | 244 (55.5%) | 237 (58.8%) | 234 (70.5%) | 264 (76.5%) | 979 (64.4%) |
| Yes | 196 (44.5%) | 166 (41.2%) | 98 (29.5%) | 81 (23.5%) | 542 (35.6%) |
| History of oophorectomy | |||||
| No | 423 (75.0%) | 462 (81.5%) | 505 (87.8%) | 493 (89.3%) | 1883 (83.4%) |
| Yes | 141 (25.0%) | 105 (18.5%) | 70 (12.2%) | 59 (10.7%) | 376 (16.6%) |
| History of salpingectomy | |||||
| No | 410 (72.3%) | 429 (75.9%) | 448 (77.8%) | 446 (80.8%) | 1734 (76.7%) |
| Yes | 157 (27.7%) | 136 (24.1%) | 128 (22.2%) | 106 (19.2%) | 527 (23.3%) |
| History of endometriosis | |||||
| No | 263 (90.4%) | 313 (94.0%) | 370 (59.8%) | 367 (91.5%) | 1313 (92.9%) |
| Yes | 28 (9.6%) | 20 (6.0%) | 18 (2.9%) | 34 (8.5%) | 100 (7.1%) |
| History of uterine fibroids | |||||
| No | 246 (84.5%) | 295 (88.9%) | 345 (89.4%) | 361 (89.6%) | 1247 (88.3%) |
| Yes | 45 (15.5%) | 37 (11.1%) | 41 (10.6%) | 42 (10.4%) | 165 (11.7%) |
| History of osteoporosis | |||||
| No | 554 (90.1%) | 554 (89.8%) | 562 (91.5%) | 568 (92.2%) | 2238 (90.9%) |
| Yes | 61 (9.9%) | 63 (10.2%) | 52 (8.5%) | 48 (7.8%) | 225 (9.1%) |
| History of osteoarthritis | |||||
| No | 566 (91.4%) | 557 (90.0%) | 569 (91.9%) | 571 (92.4%) | 2264 (91.4%) |
| Yes | 53 (8.6%) | 62 (10.0%) | 50 (8.1%) | 47 (7.6%) | 212 (8.6%) |
| History of coronary artery disease | |||||
| No | 593 (96.3%) | 601 (97.4%) | 604 (97.9%) | 595 (97.4%) | 2394 (97.2%) |
| Yes | 23 (3.7%) | 16 (2.6%) | 13 (2.1%) | 16 (2.6%) | 68 (2.8%) |
| History of hyperlipidemia | |||||
| No | 269 (61.3%) | 255 (61.3%) | 270 (66.3%) | 278 (68.6%) | 1072 (64.3%) |
| Yes | 170 (38.7%) | 161 (38.7%) | 137 (33.7%) | 127 (31.4%) | 595 (35.7%) |
| History of non-ovarian cancer | |||||
| No | 564 (91.1%) | 567 (91.6%) | 557 (90.3%) | 573 (93.2%) | 2262 (91.5%) |
| Yes | 55 (8.9%) | 52 (8.4%) | 60 (9.7%) | 42 (6.8%) | 209 (8.5%) |
SD Standard deviation, BMI Body mass index