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. 2022 May 14;20:222. doi: 10.1186/s12967-022-03408-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — SIRT1 prevented CSE-induced LF activation by regulating lipid metabolism in an autophagy-dependent pathway. A Level of SIRT1 was detected. B Effect of SIRT1 activator SRT1720 on the expression of Collagen I, α-SMA, CPT1a and PPARα. C Nile Red Staining. D, E Representative pictures of lipophagy as indicated by the co-localization of LC3 (D) or LTR (E) with Bodipy 493/503. F, G Western blot analysis for Collagen I, α-SMA, p62, LC3 I and LC3 II. H Representative pictures and numbers of autophagosomes (yellow) and autolysosomes (red). I Level of collagen I, α-SMA, CPT1a and PPARα were examined. *p < 0.05 versus control, ^#p < 0.05 versus CSE, ^&p < 0.05 versus CSE + SRT1720 (n = 3)