Table 2.
The effect of TMB level on signaling pathways
| Pathway | Variation trend | NOM p-value | Functions in cancer |
|---|---|---|---|
| Homologous recombination | Enriched in high TMB | 0.008 | Main steps in DNA double-strand break repair. |
| P53 | Enriched in high TMB | 0.000 | Tumor suppressor protein. |
| Butanoate metabolism | Enriched in low TMB | 0.017 |
1. An anticancer ingredient. 2. Butanoate metabolism is disrupted in breast cancer. |
| Tyrosine metabolism | Enriched in low TMB level | 0.008 | Tyrosine kinase family encompasses the greatest number of oncoproteins. |
| Histidine metabolism | Enriched in low TMB level | 0.028 | Histidine metabolism can increase the effectiveness of methotrexate treatment. |
| Bile acid metabolism | Enriched in low TMB level | 0.035 | Bile acids have been proposed to promote colon carcinogenesis. |
| Cytochrome P450 | Enriched in low TMB level | 0.002 | Cytochrome P450 enzymes play key roles in bile acid synthesis. |
TMB tumor mutational burden